Halozyme Therapeutics Investor Presentation — August 2021

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Second Quarter 2021 Financial Results Presentation

August 9, 2021Forward- Looking Statements

2Note: This presentation contains product names, trademarks and registered trademarks are property of their respective ownersIn addition to historical information, the statements set forth in this presentation include forward- looking statements including, without limitation, statements

concerning the Company’s expected future financial performance (including the Company's financial outlook for 2021) and expec tations for profitability,

revenue (including expectations for future milestones and royalty growth), operating income, expenses and earnings -per-share and the Company’s plans to

continue its share repurchase program and to potentially expand its platform through acquisitions. Forward -looking statements r egarding the Company’s

ENHANZE®drug delivery technology may include the possible activity, benefits and attributes of ENHANZE®, the possible method of action of ENHANZE®, its

potential application to aid in the dispersion and absorption of other injected therapeutic drugs and facilitating more rapid delivery and administration of

larger volumes of injectable medications through subcutaneous delivery and potentially lowering the treatment burden for pati ents, including the potential

extension of dosing intervals for people taking medicines for the treatment and prevention of HIV. Forward- looking statements regarding the Company's

ENHANZE®business may include potential growth driven by our partners' development and commercialization efforts (including anticipated new clinical trial

starts and ENHANZE®product launches), projections for future sales revenue of our collaborators’ products, potential new ENHANZE®collaborations and

collaborative targets and potential approvals of new ENHANZE®products. These forward- looking statements are typically, but not always, identified through

use of the words "believe," "enable," "may," "will," "could," "intends," "estimate," "anticipate," "plan," "predict," "probab le," "potential," "possible," "should,"

"continue," and other words of similar meaning and involve risk and uncertainties that could cause actual results to differ m aterially from those in the forward-

looking statements. Actual results could differ materially from the expectations contained in these forward- looking statements a s a result of several factors,

including unexpected levels of revenues (including royalty and milestone revenue received from our collaboration partners), expe nditures and costs,

unexpected delays in the execution of the Company's share repurchase program or planned platform expansion, unexpected results or delays in the growth