Halozyme Therapeutics Investor Presentation — February 2022

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Fourth Quarter and Full Year 2021 Financial Results Presentation

February 22, 2022Forward -Looking Statements

2Note: This presentation contains product names, trademarks and registered trademarks are property of their respective ownersIn addition to historical information, the statements set forth in this presentation include forward -looking statements includin g, without limitation, statements

concerning the Company’s expected future financial performance (including the Company's financial outlook for 2022) and expec tations for profitability,

revenue (including expectations for future milestones and royalties), operating income, and earnings -per-share, and the Company’ s plans to repurchase shares

under its share repurchase program and to potentially expand the Company's platform through acquisitions. Forward -looking state ments regarding the

Company’s ENHANZE®drug delivery technology may include the possible benefits and attributes of ENHANZE®including its potential application to aid in the

dispersion and absorption of other injected therapeutic drugs and facilitating more rapid delivery and administration of larg er volumes of injectable

medications through subcutaneous delivery. Forward -looking statements regarding the Company's ENHANZE®business may include potential growth driven by

our partners' development and commercialization efforts (including anticipated new clinical trial starts and ENHANZE®product approvals and launches),

projections for future sales revenue of our collaborators’ products, potential new ENHANZE®collaborations, collaborative targets and indications for ENHANZE

®products, co -formulation intellectual property and the Company’s plans to develop new formulations of its API for longer intel lectual property protection.

These forward -looking statements are typically, but not always, identified through use of the words "believe," "enable," "may," "will," "could," "intends," "estimate,"

"anticipate," "plan," "predict," "probable," "potential," "possible," "should," "continue," and other words of similar meanin g and involve risk and uncertainties that

could cause actual results to differ materially from those in the forward -looking statements. Actual results could differ materi ally from the expectations

contained in these forward -looking statements as a result of several factors, including unexpected levels of revenues (including royalty and milestone revenue

received from our collaboration partners), expenditures and costs, unexpected delays in the execution of the Company’s share repurchase program

orplanned platform expansion, unexpected results or delays in the growth of the Company’s ENHANZE®business (including as a result of unexpected