Paratek Investor Presentation — January 2018

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Corporate Presentation

January 20181/10/2018 2

Third -party industry and market information included herein has been obtained from sources believed to be reliable, but the accu racy or completeness of such

information is not guaranteed by, has not been independently verified by, and should not be construed as a representation by, Paratek . The information contained

in this presentation is accurate only as of the date hereof. “ Paratek ” and the Paratek logo are trademarks and service marks of Paratek . All other trademarks,

service marks, trade names, logos and brand names identified in this presentation are the property of their respective owners .

Certain statements in this presentation, including responses to questions, contain or may contain “forward -looking statements” w ithin the meaning of the Private

Securities Litigation Reform Act of 1995. Examples of such statements include, but are not limited to, statements about our s trategy, future operations, prospects,

plans, objectives of management, availability of data from our clinical studies, potential use of our product candidates, inc luding Omadacycline and Sarecycline ,

the market acceptance of our product candidates, the strength of, and protection offered by, our intellectual property positi on,the potential clinical risks and

efficacy of, and market opportunities for, our product candidates, the timing and stability of our supply chain, the timing o f clinical development of, and regulatory

approval for, our product candidates, and the nature and timing of our collaboration agreements with respect to our product c andidates. The words “anticipate,”

“estimate,” “expect,” “potential,” “will,” “project” and similar terms and phrases are used to identify forward -looking statemen ts. These statements are based on

current information and belief and are not guarantees of future performance. Our ability to predict results, financial or oth erwise, or the actual effect of future plans

or strategies, is inherently uncertain and actual results may differ from those predicted depending on a variety of factors. Ouroperations involve risks and

uncertainties, many of which are outside our control, and any one of which, or a combination of which, could materially affec t our results of operations or whether

the forward -looking statements ultimately prove to be correct. Except as required by law, we undertake no obligation to publicly update any forward -looking

statement, whether as a result of new information, future events or otherwise. Among the risks and uncertainties that could c ause actual results to differ materially

from those indicated by such forward -looking statements include: delays in clinical trials or unexpected results; the risk that data to date and trends may not be