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1 Breakthroughs that change patients’ lives® Breakthroughs that change patients’ lives® Efficacy and Safety of Bivalent Respiratory Syncytial Virus ( RSVpreF ) Vaccine in Older Adults IDWeek 2022, Washington, DC October 19 –23, 2022Edward E. Walsh ,1*Fernando Polack,2Agnieszka M.
1 Breakthroughs that change patients’ lives®
Breakthroughs that change patients’ lives®
Efficacy and Safety of Bivalent
Respiratory Syncytial Virus ( RSVpreF )
Vaccine in Older Adults
IDWeek 2022, Washington, DC
October 19 –23, 2022Edward E. Walsh ,1*Fernando Polack,2Agnieszka M. Zareba,3Ann R. Falsey,1Gonzalo Pérez Marc,4
Qin Jiang,3Katherine Schneider,5David Cooper,5Maria Maddalena Lino,6Annaliesa S. Anderson,5
Kathrin U. Jansen,5Kena A. Swanson,5Alejandra Gurtman,5William C. Gruber,5and
Beate Schmoele -Thoma7for the RENOIR Clinical Trial Group
1University of Rochester Medical Center, Rochester, NY; 2Fundacion INFANT, Buenos Aires, Argentina; 3Pfizer Inc, Collegeville, PA;
4iTrial -Hospital Militar Central, Buenos Aires, Argentina; 5Pfizer Inc, Pearl River, NY; 6Pfizer Srl, Milan, Italy; 7Pfizer Pharma GmbH,
*Presenting author 2 Breakthroughs that change patients’ lives®
Breakthroughs that change patients’ lives®
•Edward E. Walsh reports grants from Merck, Pfizer, and Janssen; and has served as an unpaid consultant to
Novavax, Merck, GlaxoSmithKline, and Janssen.
•Fernando Polack holds stock in iTrials SA, and is a consultant for Janssen, Merck, and Novovax .
•Ann F. Falsey reports grants from Merck, Pfizer, BioFire Diagnostics, Janssen, and CyanVac ; serves on a
Data and Safety Monitoring Board for Novavax; and is a consultant for GSK, Icosavax and Arrowhead
•Gonzalo P érez Marc has conducted clinical trials for Pfizer, Boehringer Ingelheim, Janssen, Medicago, and
•Agnieszka M. Zareba, Qin Jiang, Katherine Schneider, David Cooper, Maria Maddalena Lino,
Annaliesa S. Anderson, Kena A. Swanson, Alejandra Gurtman, William C. Gruber, and Beate Schmoele -
Thoma are Pfizer employees and may hold stock or stock options.
•Kathrin U. Jansen was a Pfizer employee at the time of the study and may hold stock or stock options.Disclosures 3 Breakthroughs that change patients’ lives®
Breakthroughs that change patients’ lives®
RSV is a hidden annual epidemic in older adults
True burden in older adults is underestimated
because testing is not routinely done and when performed is unreliable
Sources: McLaughlin J et al. Open Forum Infect Dis 2022;9:ofac300; National Foundation for Infectious Diseases. Respiratory S yncytial Virus in Older Adults: A Hidden Annual Epidemic, Sep 2016. www.nfid.org/publications/reports/rsv -report.pdf;
Falsey A et al. N Engl J Med 2005;352:1749 –1759; Matias G et al. BMC Public Health 2017;17:271; Fleming DM et al. BMC Infect Dis 2015;15:433; Matias G et al. Influenza Other Respir Viruses 2014;8:507 –515; Thompson WW et al. JAMA
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