PolyPid Investor Presentation — March 2021

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2This presentation ofPolyPid Ltd.(the “Company ”)contains “forward -looking statements ”within themeaning ofthePrivate Securities

Litigation Reform Act and other securities laws .Words such as“expects, ”“anticipates, ”“intends, ”“plans, ”“believes, ”“seeks, ”

“estimates ”and similar expressions orvariations ofsuch words areintended toidentify forward -looking statements .Forexample, the

Company isusing forward -looking statements when itdiscusses statements relating toour objectives, plans, and strategies, the

expected timing oftrials, the research, development, and use ofour platform technologies, technologies, products and product

candidates, and allstatements (other than statements ofhistorical facts) that address activities, events, ordevelopments that the

Company intends, expects, projects, believes, oranticipates will ormay occur inthe future .Forward -looking statements are not

historical facts, and arebased upon management ’scurrent expectations, beliefs and projections, many ofwhich, bytheir nature, are

inherently uncertain .Such expectations, beliefs and projections areexpressed ingood faith .However, there canbenoassurance that

management ’sexpectations, beliefs and projections willbeachieved and actual results may differ materially from what isexpressed in

orindicated bytheforward -looking statements .Forward -looking statements aresubject torisks and uncertainties that could cause

actual performance orresults todiffer materially from those expressed inthe forward -looking statements .For amore detailed

description oftherisks and uncertainties affecting theCompany, reference ismade totheCompany ’sreports filed from time totime

with theSecurities and Exchange Commission (“SEC”),including, butnotlimited to,therisks detailed intheCompany ’sAnnual Report

onForm 20-F,filed with theSEC onMarch 5,2021 .Forward -looking statements speak only asofthedate thestatements aremade .

The Company assumes noobligation toupdate forward -looking statements toreflect actual results, subsequent events or

circumstances, changes inassumptions orchanges inother factors affecting forward -looking information except totheextent required

byapplicable securities laws .Ifthe Company does update one ormore forward -looking statements, noinference should bedrawn

that theCompany willmake additional updates with respect thereto orwith respect toother forward -looking statements .Disclaimer3

Global: Petach Tikva, Israel

employees(1)PolyPid is a Phase 3 clinical -stage biopharmaceutical company

focused on developing targeted, locally administered and

prolonged release therapeutics to address diseases with high