Taysha Gene Therapies Investor Presentation — April 2021

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Bringing New Cures toLife

TSHA -120 GAN Program Acquisition –Conference Call

April 12 , 2021FORWARD LOOKING STATEMENTS

This presentation contains forward -looking statements that involve substantial risks and uncertainties. All statements, other th an statements of historical facts,

contained in this presentation, including statements regarding our strategy, future operations, future financial position, fu ture revenues, projected costs,

prospects, plans and objectives of management, are forward -looking statements. The words “anticipate,” “believe,” “estimate,” “e xpect,” “intend,” “may,” “might,”

“plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions areintended to identify forward -looking

statements, although not all forward -looking statements contain these identifying words. These forward -looking statements are su bject to a number of risks,

uncertainties and assumptions. Risks regarding our business are described in detail in our Securities and Exchange Commission filings, including in our Annual

Report on Form 10 -K for the year ended December 31, 2020. We may not actually achieve the plans, intentions or expectations disc losed in our forward -looking

statements, and you should not place undue reliance on our forward -looking statements. Actual results or events could differ mat erially from the plans, intentions

and expectations disclosed in the forward -looking statements we make. The forward -looking statements contained in this presentat ion reflect our current views

with respect to future events, and we assume no obligation to update any forward -looking statements except as required by applic able law.

This presentation includes statistical and other industry and market data that we obtained from industry publications and res earch, surveys and studies conducted

by third parties as well as our own estimates of potential market opportunities. All of the market data used in this prospect us involves a number of assumptions

and limitations, and you are cautioned not to give undue weight to such data. Industry publications and third -party research, su rveys and studies generally

indicate that their information has been obtained from sources believed to be reliable, although they do not guarantee the ac curacy or completeness of such

information. Our estimates of the potential market opportunities for our product candidates include several key assumptions b ased on our industry knowledge,

industry publications, third -party research and other surveys, which may be based on a small sample size and may fail to accurat ely reflect market opportunities.