Tonix Pharmaceuticals Holding Investor Presentation — April 2021 - Tonix Pharmaceuticals Holding Corp.

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Version P0286 4-06-2021 (Doc 0815)Investor Presentation

Certain statements inthispresentation regarding strategic plans, expectations andobjectives forfuture

operations orresults are“forward -looking statements” asdefined bythePrivate Securities Litigation Reform

Actof1995.These statements may beidentified bytheuseofforward -looking words such as“anticipate,”

“believe,” “forecast,” “estimate” and“intend,” among others .These forward -looking statements arebased on

Tonix’s current expectations andactual results could differ materially .There areanumber offactors that

could cause actual events todiffer materially from those indicated bysuch forward -looking statements. These

factors include, butarenotlimited to,risks related tofailure toobtain U.S.Food andDrug Administration

clearances orapprovals andnoncompliance withitsregulations ;ourneed foradditional financing ;delays and

uncertainties caused bytheglobal COVID -19pandemic; substantial competition ;uncertainties ofpatent

protection andlitigation ;uncertainties ofgovernment orthird party payor reimbursement ;limited research

anddevelopment efforts anddependence upon third parties .Aswithanypharmaceutical under development,

there aresignificant risks inthedevelopment, regulatory approval andcommercialization ofnewproducts .

Theforward -looking statements inthispresentation aremade asofthedate ofthispresentation, even if

subsequently made available byTonix onitswebsite orotherwise .Tonix does notundertake anobligation to

update orrevise anyforward -looking statement, except asrequired bylaw.Investors should read therisk

factors setforth intheAnnual Report onForm 10-Kfortheyearended December 31,2020,asfiledwiththe

Securities andExchange Commission (the“SEC”) onMarch 15,2021, andperiodic reports andcurrent reports

filed with theSEConorafter thedate thereof .AllofTonix's forward -looking statements areexpressly

Who We Are –Mission And Purpose

Clinical- stage biopharmaceutical company that invents and develops medicines to

help patients manage the central nervous system (CNS) and immunology diseases.

CANDIDATES INDICATION STATUS

PortfolioTNX-102 SL1Fibromyalgia (FM) -Lead Program Mid-Phase 3 –ongoing