Varian Medical Systems Investor Presentation — January 2018

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President and Chief Executive OfficerJanuary 30, 2018Acquisition of SIRTeX

This presentation is intended exclusively for investors.

It is not intended for use in Sales or Marketing.

2Forward -Looking Statements

Except forhistorical information, thispresentation contains forward -looking statements within themeaning ofthePrivate Securities Litigation

Reform Actof1995 .Statements concerning industry outlook, including growth drivers, future trends incancer incidence andtrends incancer

treatment needs, demand, innovation and growth opportunities ;Varian Medical Systems, Inc.’s(”Varian” orthe“company”) future orders,

revenues, backlog orearnings growth ;future financial results ;anystatements concerning Varian’s planned acquisition ofSirtex ;expected

closing date;Varian’s financing plans ;thecompany’s future orders, revenues, orearnings growth orother financial results ;andanystatements

using theterms “could”, “believe”, “expect”, “outlook”, “anticipate”, ”vision”, “estimate”, “future”, “horizon”, “aiming”, “driving”, “target” orsimilar

statements areforward -looking statements that involve risks and uncertainties that could cause thecompany’s actual results todiffer

materially from those anticipated .Such risks anduncertainties include timing ofregulatory approvals ;theavailability ofterms ofdebt financing ;

theability tointegrate theSirtex business ;global economic conditions andchanges totrends forcancer treatment regionally ;thecompany’s

ability tomeet Food andDrug Administration (FDA) andother regulatory requirements forproduct clearances ortocomply withFDA andother

regulatory regulations orprocedures, changes intheregulatory environment, including with respect toFDA requirements ;andtheother risks

listed from time totime inthecompany’s filings with theSecurities and Exchange Commission, which bythisreference areincorporated

herein .The company assumes noobligation toupdate orrevise theforward -looking statements inthis presentation because ofnew

information, future events, orotherwise .Reconciliations toGAAP financials canbefound athttp://investors .varian .com/financialstatements

andtheappendix tothispresentation .

Medical Advice Disclaimer

Varian as a medical device manufacturer cannot and does not recommend specific treatment approaches. Individual treatment res ults may

•Builds on our foundation as a global leader in radiation medicine

•Adds platform to enter fast -growing interventional oncology market

•Extends our oncology customer base to accelerate revenue

•Leverages our global operations, treatment planning, oncology practice