Vertex Pharmaceuticals Investor Presentation — August 2022

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Investor Presentation

Copyright © 2022 Vertex, Inc. All rights reserved. Proprietary and confidential.Disclaimer

Copyright © 2022 Vertex, Inc. All rights reserved. Proprietary and confidential.Forward Looking Statements

Any statements made inthispresentation that arenotstatements ofhist orical fact, including statements about ourbeliefs and expectations, areforward -looki ng statements andshould beevaluated assuch .Forward -looking statements i nclude information concerni ng possi ble or

assumed future results ofoperations, incl udi ng descripti ons ofourbusine ss plan andstrategies .Forward -looking statements arebased onVertex management’s beliefs, aswell asassumpti ons made by,and information currently available to,them .B ecause such statement s are

based onexpectations astofut ure financial and operating results a ndarenotstatements offa ct, actual result s may differ materially from those projected .Factors w hich may cause actual result s todiffer materially from current expectations include, butarenotlimited to:pote ntial

effects onourbusine ss oftheCOVID -19pandemic ;ourability toattract new customers onacost-effective basi s and theextent towhich existing cust omers renew and upgrade their subscri ptions ;ourability tosustain and expa nd revenues, maintain pr ofitability, andtoeffectively

manage ouranticipated growth ;ourability tomaintain andexpand ourstrategic relationships with thir d parties ;and t heother factors describe d under theheading “Risk Factor s” intheCompa ny’s A nnual Report onForm 10-Kfortheyear ended December 31,2021 asfiled with t he

Securities Exchange Commission (“SE C”) a nd t heCom pany’s subsequent filing s with t heSEC.Copie s ofeach fili ng may beobtained from theCompany ort heSEC.Allforward -looking statements reflect ourbeliefs and a ssumpti ons only asoft hedate oft hispresentation .We

undertake noobligation toupdate forward -looking statements toreflect future events orcircumstances .

Definitions ofCertain Key Business Metrics

Annual Recurring Revenue (“ARR”) –Wederive thevast majority ofourrevenue s from recurring software subscriptions .Webelieve ARR provi des uswith vi sibility toourprojected software subscription revenues inorder toevaluate thehealth ofourbusine ss .Because werecognize

subscri ption revenues ratably, webelieve investor s canuseARR tomeasure ourexpansion ofexisti ng cust omer revenues, new customer activity, and asani ndi cator offuture software subscripti on revenues .ARR isba sed onmonthl y recurring revenues (“MRR”) from software

subscri ptions forthemost recent month atperiod end, multiplied bytwelve .MRR iscalculated bydivi ding t hesoftware subscription price, incl usive ofdiscounts, bythenum ber ofsubscripti on covered months .MRR only i ncludes cust omers with MRR attheend oft helastmont h of