Vertex Pharmaceuticals Investor Presentation — May 2024

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Copyright © 2024 Vertex, Inc. All rights reserved. Proprietary and confidential.Investor Presentation

May 2024Copyright © 2024 Vertex, Inc. All rights reserved. Proprietary and confidential.

Forward Looking Statements

Any statements made inthis presentation that arenotstatements ofhistorical fact, including statements about ourbeliefs and expectations, areforward -looking statements and should beevaluated assuch .Forward -looking statements include information concerning possible orassumed

future results ofoperations, including descriptions ofour business plan and strategies. Forward -looking statements are based onVertex management’s beliefs, aswell asassumptions made by,and information currently available to,them .Because such statements arebased on

expectations astofuture financial and operating results and arenotstatements offact, actual results may differ materially from those projected .Factors which may cause actual results todiffer materially from current expectations include, butarenotlimited to:ourability toattract new

customers onacost-effective basis and theextent towhich existing customers renew and upgrade their subscriptions ;ourability tosustain and expand revenues, maintain profitability, and toeffectively manage ouranticipated growth ;ourability tomaintain and expand ourstrategic

relationships with third parties ;and theother factors described under theheading “Risk Factors” intheCompany’s Annual Report onForm 10-Kfortheyear ended December 31,2023 asfiled with theSecurities Exchange Commission (“SEC”) and theCompany’s subsequent filings with the

SEC.Copies ofeach filing may beobtained from the Company orthe SEC.Allforward -looking statements reflect our beliefs and assumptions only asofthe date ofthis presentation .We undertake noobligation toupdate forward -looking statements toreflect future events or

Definitions ofCertain Key Business Metrics

Annual Recurring Revenue (“ARR”) –We derive thevast majority ofour revenues from recurring software subscriptions .We believe ARR provides uswith visibility toourprojected software subscription revenues inorder toevaluate thehealth ofour business .Because werecognize

subscription revenues ratably, webelieve investors canuseARR tomeasure ourexpansion ofexisting customer revenues, new customer activity, and asanindicator offuture software subscription revenues .ARR isbased onmonthly recurring revenues (“MRR”) from software subscriptions

forthemost recent month atperiod end, multiplied bytwelve .MRR iscalculated bydividing thesoftware subscription price, inclusive ofdiscounts, bythenumber ofsubscription covered months .MRR only includes customers with MRR attheend ofthelast month ofthemeasurement

Net Revenue Retention Rate (“NRR”) –Webelieve that ourNRR provides insight into ourability toretain and grow revenues from ourcustomers, aswell astheir potential long -term value tous.Wealso believe itdemonstrates toinvestors ourability toexpand existing customer revenues,