Wave Life Sciences Investor Presentation — May 2021

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Corporate Presentation

May 13, 20212Forward -looking statements

Thisdocument contains forward -looking statements .Allstatements other thanstatements ofhistorical facts contained inthis

document, including statements regarding possible orassumed future results ofoperations, preclinical andclinical studies,

business strategies, research anddevelopment plans, collaborations andpartnerships, regulatory activities andtiming thereof,

competitive position, potential growth opportunities, useofproceeds andtheeffects ofcompetition areforward -looking

statements .These statements involve known andunknown risks, uncertainties andother important factors thatmaycause

theactual results, performance orachievements ofWave LifeSciences Ltd.(the“Company”) tobematerially different from

anyfuture results, performance orachievements expressed orimplied bytheforward -looking statements .Insome cases, you

canidentify forward -looking statements byterms such as“may,” “will,” “should,” “expect,” “plan,” “aim,” “anticipate,” “could,”

“intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or“continue” orthenegative ofthese

terms orother similar expressions. Theforward -looking statements inthispresentation areonlypredictions .TheCompany has

based these forward -looking statements largely onitscurrent expectations andprojections about future events andfinancial

trends thatitbelieves mayaffect theCompany’s business, financial condition andresults ofoperations .These forward -looking

statements speak onlyasofthedateofthispresentation andaresubject toanumber ofrisks, uncertainties andassumptions,

including those listed under RiskFactors intheCompany’s Form 10-Kandother filings withtheSEC, some ofwhich cannot be

predicted orquantified andsome ofwhich arebeyond theCompany’s control .Theevents andcircumstances reflected inthe

Company’s forward -looking statements maynotbeachieved oroccur, andactual results could differ materially from those

projected intheforward -looking statements .Moreover, theCompany operates inadynamic industry andeconomy .Newrisk

factors anduncertainties mayemerge from timetotime, anditisnotpossible formanagement topredict allriskfactors and

uncertainties thattheCompany mayface.Except asrequired byapplicable law,theCompany does notplantopublicly update

orrevise anyforward -looking statements contained herein, whether asaresult ofanynewinformation, future events,

changed circumstances orotherwise .3Building a leading genetic medicines company

ALS: Amyotrophic lateral sclerosis; FTD: Frontotemporal dementia