Halozyme Therapeutics Investor Presentation — November 2021

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Third Quarter 2021 Financial Results Presentation

November 2, 2021Forward -Looking Statements

2Note: This presentation contains product names, trademarks and registered trademarks are property of their respective ownersIn addition to historical information, the statements set forth in this presentation include forward -looking statements includin g, without limitation, statements

concerning the Company’s expected future financial performance (including the Company's financial outlook for 2021) and expec tations for profitability,

revenue (including expectations for future milestones and royalty growth), operating income, expenses and earnings -per-share, an d to potentially expand the

Company's platform through acquisitions. Forward -looking statements regarding the Company’s ENHANZE®drug delivery technology may include the

possible activity, benefits and attributes of ENHANZE®, the possible method of action of ENHANZE®, its potential application to aid in the dispersion and

absorption of other injected therapeutic drugs and facilitating more rapid delivery and administration of larger volumes of i njectable medications through

subcutaneous delivery and potentially lowering the treatment burden for patients. Forward -looking statements regarding the Compa ny's ENHANZE®business

may include potential growth driven by our partners' development and commercialization efforts (including anticipated new cli nical trial starts and

ENHANZE®product launches), projections for future sales revenue of our collaborators’ products, potential new ENHANZE®collaborations and collaborative

targets and potential approvals of new ENHANZE®products. These forward -looking statements are typically, but not always, identified through use of the

words "believe," "enable," "may," "will," "could," "intends," "estimate," "anticipate," "plan," "predict," "probable," "poten tial," "possible," "should," "continue," and

other words of similar meaning and involve risk and uncertainties that could cause actual results to differ materially from t hose in the forward -looking

statements. Actual results could differ materially from the expectations contained in these forward -looking statements as a resu lt of several factors, including

unexpected levels of revenues (including royalty and milestone revenue received from our collaboration partners), expenditure s and costs, unexpected

delays in the execution of the Company's planned platform expansion, unexpected results or delays in the growth of the Company’ s ENHANZE®business, or in

the development, regulatory review or commercialization of ENHANZE®products, including any potential delays caused by the current COVID -19 global